Loch Lomond Distillery is a large, utilitarian facility with almost no aesthetic design elements, lacking a visitor centre, and built primarily for production. It is located in an industrial area on the edge of Alexandria, about a mile and a half from Loch Lomond. The distillery was constructed between 1965-1966, repurposing a former dyeing plant of the once-famous United Turkey Red Company. The project was completed by American-born Littlemill distillery owner Duncan Thomas in collaboration with his US agent, Chicago-based Barton Brands. The latter acquired Duncan Thomas' remaining shares in Littlemill and Loch Lomond in 1971. At this time, Loch Lomond produced two styles of whisky: Rossdhu and Inchmurrin, from a pair of distillation units equipped with rectifying heads (see below). After the building renovation, it became the first distillery to install specialized distillation equipment. Like many distilleries, Loch Lomond was mothballed in 1984, then sold to Inver House Distilleries in 1985, which subsequently sold it to Glen Catrine Bonded Warehouse Company Ltd the following year. This company is a bottling subsidiary of the family-owned beverage wholesaler (and then retailer) A. Bulloch & Company, who purchased the business to ensure the supply of malt whisky. In 1992, the distillery added a second distillation unit—a replica of the first pair of stills, complete with rectifying heads; in 1994, a new Coffey still was installed for grain whisky production; in 1998, a third pair of traditional pot stills with narrow necks was added; and between 2007-2008, a fourth pair was installed, along with a unique improved Coffey still for malt whisky production. In March 2014, Loch Lomond Distillery Ltd was acquired for £210 million by a group of senior managers backed by the private equity firm Exponent. The deal also included Glen Scotia Distillery (see "Glen Scotia"), Glen Catrine Bonded Warehouse Company's bottling plant and warehouse in Ayrshire, and various other brands. The new owners have invested more than £10 million in the business and installed two new stills and three new fermenters at Loch Lomond Distillery.

By combining different peat levels, Loch Lomond's versatile stills can produce eight distinct styles of both malt and grain whisky, making the distillery virtually self-sufficient for blending. While most of their production has historically been used for their renowned High Commissioner blended whisky (particularly for export markets), the new ownership has actively promoted various single malt expressions as well as premium single grain whiskies. Currently, only Girvan/Ailsa Bay (see relevant entry) operates both malt and grain whisky production at a single site. Loch Lomond's distinctive rectifier heads on their pot stills, inspired by grain distillery designs, feature perforated plates (similar to continuous stills) that enable the creation of whiskies at different strengths and purities, reaching up to 85% ABV—surpassing the 70% limit of traditional pot stills. Utilizing modernized Coffey stills, spirit can be drawn at different strength points throughout the column, offering greater control and stability compared to modified pot stills. Loch Lomond is Britain's largest freshwater loch, measuring 24 miles long, 5 miles wide, and 600 feet deep, with 38 islands. It has been a world-famous beauty spot since the 18th century. The traditional song 'The Bonnie Banks o' Loch Lomond' commemorates two Jacobite prisoners held in Carlisle after the 1745 rebellion—one executed, the other released to return home by the 'low road'.